SQSTM1 Rabbit pAb

Enables K63-linked polyubiquitin modification-dependent protein binding activity, identical protein binding activity, and ionotropic glutamate receptor binding activity. Involved in several processes, including brown fat cell proliferation, energy homeostasis, and positive regulation of long-term synaptic potentiation. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in several cellular components, including aggresome, autolysosome, and sperm midpiece. Is expressed in several structures, including alimentary system, central nervous system, genitourinary system, limb, and sensory organ. Used to study Paget's disease of bone. Human ortholog(s) of this gene implicated in GNE myopathy, Paget's disease of bone, and frontotemporal dementia and/or amyotrophic lateral sclerosis-3. Orthologous to human SQSTM1 (sequestosome 1). Synonyma: Osi, p62, A170, STAP, OSF-6, STONE14, SQSTM1