TROP-2 Rabbit pAb

Involved in several processes, including negative regulation of branching involved in ureteric bud morphogenesis, negative regulation of cellular component organization, and negative regulation of substrate adhesion-dependent cell spreading. Acts upstream of or within positive regulation of stem cell differentiation, regulation of epithelial cell proliferation, and ureteric bud morphogenesis. Located in several cellular components, including basal plasma membrane, extracellular space, and lateral plasma membrane. Is expressed in alimentary system, genitourinary system, sensory organ, and skin. Human ortholog(s) of this gene implicated in corneal dystrophy and gelatinous drop-like corneal dystrophy. Orthologous to human TACSTD2 (tumor associated calcium signal transducer 2). Synonyma: Ly97, EGP-1, TROP2, GA733-1