Integrin beta 1 Rabbit pAb

Enables integrin binding activity involved in cell-matrix adhesion and signaling receptor activity. Contributes to laminin binding activity. Involved in several processes, including basement membrane organization, cellular response to low-density lipoprotein particle stimulus, and regulation of synapse pruning. Acts upstream of or within with a negative effect on reactive gliosis and regulation of spontaneous synaptic transmission. Acts upstream of or within several processes, including circulatory system development, neuron projection morphogenesis, and regulation of transmembrane transport. Located in several cellular components, including intercalated disc, myelin sheath abaxonal region, and sarcolemma. Part of integrin alpha7-beta1 complex and integrin alpha9-beta1 complex. Is active in Schaffer collateral - CA1 synapse, cerebellar climbing fiber to Purkinje cell synapse, and synaptic membrane. Colocalizes with cytoplasmic vesicle, perinuclear region of cytoplasm, and plasma membrane. Is expressed in several structures, including alimentary system, brain, eye, genitourinary system, and heart. Used to study Hirschsprung's disease. Orthologous to human ITGB1 (integrin subunit beta 1).