HBL-52 Cells

HBL-52 is a human cell line derived from a transitional meningioma grade I, specifically localized at the optic canal. This cell line originates from a female adult patient and exhibits epithelial-like morphology. Meningiomas are typically benign tumors that arise from the meninges, the membranous layers surrounding the brain and spinal cord. The transitional subtype represents a histological category where the tumor cells demonstrate a mixture of fibrous and meningothelial characteristics. Recent studies have highlighted the responsiveness of HBL-52 cells to resveratrol, a naturally occurring polyphenol with significant anti-inflammatory and anticancer properties. Resveratrol has been found to inhibit proliferation in HBL-52 meningioma cells, suggesting a potential therapeutic role in managing or treating meningiomas, particularly those located in critical areas like the optic canal. This inhibition of cell proliferation highlights the utility of HBL-52 in pharmacological research and drug testing, providing a valuable model for assessing the efficacy of compounds that may influence tumor growth dynamics. Given its origin and benign nature, the HBL-52 cell line is a valuable model for studying meningioma pathogenesis, particularly in understanding the cellular behaviors and molecular mechanisms underlying the development and progression of meningiomas at unique anatomical sites like the optic canal. Brain cancer cell lines, Brain, Meningioma, benign cells, Growth Conditions: Adherent, Biosafety level: BSL 1