TF-1 Cells

TF-1 cells are erythroblasts isolated from the bone marrow of a 35-year-old Asian male diagnosed with severe pancytopenia in 1987. These cells are a pivotal model for studying the complex processes of proliferation and differentiation within myeloid progenitor cells. As a cell line, TF-1 is heavily utilized in hematological research to understand the underlying mechanisms that govern cell cycle regulation and development in myeloid lineages. In addition to their primary role in hematopoietic research, TF-1 cells serve as a robust system for examining the impact of various cytokines on cell survival and growth. Their dependence on specific growth factors such as granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) for proliferation makes them an excellent tool for studying cytokine-mediated signaling pathways. This characteristic also makes TF-1 cells useful in evaluating the efficacy of new pharmacological agents that aim to modulate these pathways, thereby contributing significantly to therapeutic advances in treating myeloid disorders and other related diseases. Leukemia cell lines, Bone marrow, Erythroleukemia, Growth Conditions: Suspension, Biosafety level: BSL 1