M1 Cells

M1 Cells
M1 Cells
M1 cells are a widely used murine macrophage cell line, originally derived from mouse bone marrow. T...
17 303,00Kč
Cena bez DPH: 14 300,00Kč
  • Výrobce: Cytion
  • Kód výrobce: CYT-305261

Dostupné možnosti

M1 cells are a widely used murine macrophage cell line, originally derived from mouse bone marrow. They are particularly noted for their ability to differentiate into mature macrophages in response to various stimuli, such as the exposure to macrophage colony-stimulating factor (M-CSF) or certain cytokines. This makes M1 cells an invaluable tool for studying macrophage biology, including the processes of macrophage activation, polarization, and the immune response. Their use is common in research focused on inflammatory responses, innate immunity, and the mechanisms underlying macrophage differentiation and function. M1 cells are often utilized in studies that investigate the role of macrophages in inflammation and their interactions with other immune cells. The M1 polarization, also known as classical activation, is typically induced by interferon-gamma (IFN-γ) or bacterial products like lipopolysaccharide (LPS). These M1-polarized macrophages are characterized by their production of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-12, and their ability to generate reactive oxygen and nitrogen species. Due to these properties, M1 cells serve as a model to explore the molecular mechanisms of inflammation and host defense against pathogens. Furthermore, M1 cells provide a useful model for exploring the differences between various macrophage phenotypes, such as M1 (pro-inflammatory) and M2 (anti-inflammatory) macrophages, contributing to a deeper understanding of the dynamic roles macrophages play in health and disease. Their ability to be manipulated in vitro offers researchers a controlled environment to study these complex processes, advancing the field of immunology and therapeutic development. When cultured on permeable supports, M1 cells develop a lumen-negative transepithelial potential difference, which is a hallmark of functional epithelial cells. This property, along with their ability to mimic CCD cell behavior, makes M1 cells an excellent model for research into renal physiology, particularly in understanding the cellular mechanisms that govern ion transport, fluid balance, and the overall function of the kidney's cortical collecting duct. Additionally, M1 cells are instrumental in studies exploring the role of macrophages in inflammation and their interactions with other immune cells, with a focus on the pro-inflammatory M1 polarization. Mouse cell lines, Kidney, cortical collecting duct, Growth Conditions: Adherent, Biosafety level: BSL 1
Technické specifikace
Doprava a skladování Adherent
Poznámka k dopravě Dopravné k objednávce je závislé na BLS třídě dodávaných produktů a na konkrétních podmínkách přepravy. Před objednáním nás prosím kontaktujte a naši pracovníci Vám vždy cenu dopravy vyčíslí pro každý jednotlivý případ. Každá viála obsahuje celkem přibližně 3 miliony adherentních buněk nebo 5 milionů suspenzních buněk s typickou životaschopností po rozmrazení v rozmezí 80-95 %. Tyto údaje slouží jako obecné vodítko; ačkoli dodržujeme přísné normy kvality, přesné počty buněk a životaschopnost se mohou lot-to-lot lišit a nejsou zaručeny.
Vlastnosti
Původ Mouse
Specifita Mouse cell lines
500 reakcí (50 ml)..
5 242,00Kč
Cena bez DPH:4 332,23Kč
Přidat do nabídky
1000 reakcí (100 ml)..
9 370,00Kč
Cena bez DPH:7 743,80Kč
Přidat do nabídky
myší ouška (50 ml)..
5 051,00Kč
Cena bez DPH:4 174,38Kč
Přidat do nabídky
myší ouška (25 ml)..
3 018,00Kč
Cena bez DPH:2 494,21Kč
Přidat do nabídky
buněčná kultura (100 ml)..
5 051,00Kč
Cena bez DPH:4 174,38Kč
Přidat do nabídky
buněčná kultura (50 ml)..
3 018,00Kč
Cena bez DPH:2 494,21Kč
Přidat do nabídky
žloutkový váček (100 ml)..
5 051,00Kč
Cena bez DPH:4 174,38Kč
Přidat do nabídky
žloutkový váček (50 ml)..
3 018,00Kč
Cena bez DPH:2 494,21Kč
Přidat do nabídky
500 testů myší ocásky (100 ml)..
5 051,00Kč
Cena bez DPH:4 174,38Kč
Přidat do nabídky
250 testů myší ocásky (50 ml)..
3 018,00Kč
Cena bez DPH:2 494,21Kč
Přidat do nabídky