SNU-16 Cells

The SNU-16 cell line is derived from a poorly differentiated gastric carcinoma of a human adult. This cell line is extensively used in gastric cancer research, offering a model to study the molecular and cellular mechanisms involved in the development and progression of gastric adenocarcinoma. SNU-16 cells are particularly valuable for investigating genetic alterations, signal transduction pathways, and the tumor microenvironment associated with this aggressive form of stomach cancer. SNU-16 cells exhibit an epithelial morphology and are characterized by the expression of gastric carcinoma markers, including carcinoembryonic antigen (CEA) and various cytokeratins. They are known to possess amplification of the c-MET gene and overexpression of the MET receptor, which plays a significant role in cell growth, survival, and metastasis. Researchers use SNU-16 cells to explore the role of the MET signaling pathway in gastric cancer and to evaluate the efficacy of MET inhibitors and other targeted therapies. Additionally, SNU-16 cells are utilized in drug resistance studies, high-throughput screening assays, and preclinical testing of new chemotherapeutic agents. The relevance of the SNU-16 cell line in gastric cancer research underscores its importance in advancing our understanding of the disease and developing more effective treatment strategies for gastric cancer patients. Gastric cancer cell lines, Stomach, Adenocarcinoma, Growth Conditions: Suspension, multicellular aggregates, Biosafety level: BSL 1