P-815 Cells

P815 is a mastocytoma cell line derived from the DBA/2 mouse strain. This cell line is a valuable model in immunology, particularly for studying mast cell biology, immune recognition, and the mechanisms of tumor rejection. P815 cells are known for their ability to express a variety of surface antigens and for their use in the study of antigenic modulation and differentiation in mast cells. Notably, P815 cells are also widely used in assays to evaluate the cytotoxic activity of natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). Their high susceptibility to lysis by these immune cells makes them ideal for use in various immunological assays, including the standard chromium release assay for measuring cell-mediated cytotoxicity. Additionally, P815 cells have been employed in genetic studies, particularly those involving the manipulation of genes that affect cell surface antigen presentation and immune evasion strategies. Mouse cell lines, Hematopoietic, Mastocytoma, Growth Conditions: Suspension, some adherent cells, Biosafety level: BSL 1