V79-4 Cells

The V79-4 cell line is a subline of the original V79 Chinese hamster lung fibroblasts, a lineage that traces back to its development by Ford and Yerganian in 1958 from lung tissue of a young male Chinese hamster. Initially named "Strain V," the cell line was later renamed "V-79" by Elkind in 1958. In 1966, E.H.Y. Chu, having received the line from W. Sinclair, further isolated the sub-clone V79-4. This detailed lineage highlights the meticulous efforts to create a stable and reliable fibroblast cell model, which has since become a cornerstone in various biological research applications. The V79-4 cell line is particularly renowned for its use in genetic toxicology studies, including assays that investigate mutagenesis, cytotoxicity, and DNA repair mechanisms. One of its key applications is in the study of radiation-induced damage and cellular responses to genotoxic agents, such as in the micronucleus assay. Researchers favor this cell line for its stable karyotype, fibroblast-like morphology, and rapid growth rate, making it an ideal tool for experiments requiring consistent and reproducible results in mammalian cell models. In addition to its role in mutagenesis studies, V79-4 cells are frequently utilized to evaluate the effects of chemical mutagens and pharmaceuticals on cellular integrity. Their robust nature and well-characterized response to genotoxic stress make them highly valuable in studies focused on DNA damage, repair pathways, and the cellular mechanisms involved in maintaining genomic stability. As such, V79-4 cells are a widely trusted model in research fields that include cancer biology, pharmacology, and environmental toxicology. Hamster cell lines, Lung, Fibroblast, Growth Conditions: Monolayer, adherent, Biosafety level: BSL 1