BUB1B Rabbit pAb

This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. Synonyma: MVA1, SSK1, BUBR1, Bub1A, MAD3L, hBUBR1, BUB1beta, BUB1B