Cleaved PARP (Asp214) Rabbit pAb

Enables NAD+ ADP-ribosyltransferase activity, chromatin binding activity, and protein ADP-ribosylase activity. Involved in negative regulation of telomere maintenance via telomere lengthening, positive regulation of single strand break repair, and voluntary musculoskeletal movement. Acts upstream of or within several processes, including DNA metabolic process, behavioral response to cocaine, and protein poly-ADP-ribosylation. Located in cytoplasm, nucleolus, and nucleoplasm. Part of protein-containing complex. Is expressed in several structures, including Peyer's patch, brain, gut, immune system, and retina. Human ortholog(s) of this gene implicated in several diseases, including arthritis, bacterial meningitis, neurodegenerative disease (multiple), stomach carcinoma, and type 2 diabetes mellitus. Orthologous to human PARP1 (poly(ADP-ribose) polymerase 1). Synonyma: PARP, PPOL, ARTD1, Adprp, Adprt1, msPARP, parp-1, sPARP-1, 5830444G22Rik, Cleaved PARP (Asp214)