ABflo® 647 Rabbit anti-Mouse CD107b mAb

Enables protein domain specific binding activity. Involved in several processes, including autophagosome maturation, protein stabilization, and protein targeting to lysosome involved in chaperone-mediated autophagy. Acts upstream of or within muscle cell cellular homeostasis. Located in late endosome membrane, lysosomal membrane, and phagocytic vesicle membrane. Is integral component of autophagosome membrane. Is expressed in central nervous system, egg cylinder, lung, and retina. Used to study Danon disease. Human ortholog(s) of this gene implicated in Danon disease and hypertrophic cardiomyopathy. Orthologous to human LAMP2 (lysosomal associated membrane protein 2). Synonyma: Mac3, LGP-B, CD107b, Lamp-2, Lamp II, Lamp-2a, Lamp-2b, Lamp-2c