Anti-Lambda Light Chain FITC

Lambda Light Chain, Clone C-D3H is a 22.5 kDa small polypeptide subunit of Immunoglobulin. It specifically bindswith both soluble and membrane bound human lambda light chain of immunoglobulin but not binds with thekappa light chain or heavy chain. Lambda light chains are primarily expressed on the surface of B cells in lymphoidtissues. Each B cell expresses only one class of light chain kappa or lambda. In serum of a healthy individual, thetotal kappa to lambda ratio is approximately 3:1 while measuring as intact whole antibodies or 1:1.5 whilemeasuring as free light chains. Various clinical research data claim that any highly divergent ratio of kappa tolambda indicative of neoplasm. It is useful in the identification of multiple myeloma, a cancer of plasma cells.