B95-8 Cells

The B95-8 cell line is an immortalized marmoset B lymphoblastoid line, derived from the peripheral blood leukocytes of a cotton-top marmoset (Saguinus oedipus). This cell line was established through infection with the Epstein-Barr virus (EBV), which is a common method for immortalizing B cells. The presence of EBV is central to the B95-8 line's utility in research, particularly for studies related to viral oncology, virus-host interactions, and the biology of EBV itself. B95-8 cells are frequently used as a source of Epstein-Barr virus in virology research. They produce infectious virus particles, making them an invaluable tool for the propagation of EBV and for experiments requiring active virus. Additionally, this cell line has been instrumental in the development of vaccines and therapeutic strategies against EBV-associated diseases, including Burkitt's lymphoma and Hodgkin's lymphoma. The cells are also relevant in the study of the immune response to EBV, as they can be used to model the transformation of B cells and to understand the mechanisms of EBV-induced tumorigenesis.