Anti-TGN38/46

TGN38, also known as TGN46, is a type 1 integral membrane protein which predominantly localizes to the trans-Golgi network (TGN), and rapidly cycles to and from the cell surface. The cytosolic domain of TGN38/46 is involved in the reversible recruitment to the membrane with other cytosolic proteins for vesicle formation, while the luminal domain is involved in maintaining the morphology of the TGN (Banting, G., Ponnambalam, S., 1997). The cytosolic domain of TGN38/46 forms a complex with rab6, a small GTP-binding protein, and p62 where vesicle formation occurs at the exit sites of the TGN (Jones, S.M., et al, 1993). TGN38 is widely used as a reliable Golgi marker.