RCHY1 Rabbit mAb

The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. Synonyma: ZCHY, ARNIP, CHIMP, PIRH2, RNF199, ZNF363, PRO1996, RCHY1