Caspase-1 Rabbit pAb

Enables cysteine-type endopeptidase activity. Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of interleukin-1 beta production, and protein autoprocessing. Acts upstream of or within several processes, including membrane hyperpolarization, mitochondrial depolarization, and positive regulation of interleukin-1 alpha production. Located in extracellular region. Part of IPAF inflammasome complex. Is expressed in knee joint and metanephros. Orthologous to human CASP1 (caspase 1). Synonyma: ICE, Il1bc, CASP1