[KO Validated] MSH2 Rabbit mAb

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. Synonyma: FCC1, COCA1, HNPCC, LCFS2, MSH-2, hMSH2, HNPCC1, LYNCH1, MMRCS2, H2