ABflo® 488 Rabbit anti-Mouse JAM-1/CD321 mAb

Predicted to enable PDZ domain binding activity, integrin binding activity, and protein homodimerization activity. Involved in intestinal absorption, regulation of cytokine production, and regulation of membrane permeability. Acts upstream of or within cell adhesion and epithelial cell differentiation. Located in bicellular tight junction. Is expressed in several structures, including 4-8 cell stage embryo, alimentary system, respiratory system, sensory organ, and urinary system. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human F11R (F11 receptor). Synonyma: JAM, Jcam, JAM-1, JAM-A, Jcam1, Ly106, ESTM33, 9130004G24, JAM-A/CD321