APC Rat anti-Mouse CD86 mAb

Predicted to enable signaling receptor binding activity. Involved in several processes, including CD40 signaling pathway, activation of phospholipase C activity, and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including cellular response to lipopolysaccharide, defense response to virus, and positive regulation of T cell proliferation. Located in external side of plasma membrane and intracellular membrane-bounded organelle. Is expressed in central nervous system and retina. Used to study Guillain-Barre syndrome. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura, autoimmune disease (multiple), chronic lymphocytic leukemia, chronic obstructive pulmonary disease, and systemic scleroderma. Orthologous to human CD86 (CD86 molecule). Synonyma: B7, B70, MB7, B7-2, B7.2, CLS1, Ly58, ETC-1, Ly-58, MB7-2, Cd28l2, TS/A-2, CD86