ABflo® 647 Rabbit anti-Mouse CD40 mAb

Predicted to enable antigen binding activity, protein domain specific binding activity, and ubiquitin protein ligase binding activity. Involved in B cell mediated immunity, CD40 signaling pathway, and cellular calcium ion homeostasis. Acts upstream of or within several processes, including defense response to other organism, positive regulation of B cell activation, and positive regulation of interleukin-12 production. Located in external side of plasma membrane and intracellular membrane-bounded organelle. Part of CD40 receptor complex. Is expressed in several structures, including alimentary system, brain, hemolymphoid system gland, liver and biliary system, and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease, autoimmune disease (multiple), end stage renal disease, hyperimmunoglobulin syndrome (multiple), and non-Hodgkin lymphoma (multiple). Orthologous to human CD40 (CD40 molecule). Synonyma: IGM, p50, Bp50, GP39, IMD3, TRAP, HIGM1, T-BAM, Tnfrsf5