ABflo® 488 Rabbit anti-Mouse RANK/CD265 mAb

Enables tumor necrosis factor-activated receptor activity. Involved in several processes, including circadian temperature homeostasis, positive regulation of fever generation by positive regulation of prostaglandin secretion, and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development, mammary gland alveolus development, and positive regulation of bone resorption. Located in cell surface. Is expressed in bladder and lymphatic system. Human ortholog(s) of this gene implicated in Paget's disease of bone, autosomal recessive osteopetrosis 7, bone development disease, familial expansile osteolysis, and osteoporosis. Orthologous to human TNFRSF11A (TNF receptor superfamily member 11a). Synonyma: OFE, ODFR, Rank, Ly109, mRANK, TRANCE-R