ABflo® 647 Rabbit anti-Mouse Flt3/CD135 mAb

Enables several functions, including phosphatidylinositol 3-kinase binding activity, protein tyrosine kinase activity, and ubiquitin protein ligase binding activity. Involved in several processes, including common myeloid progenitor cell proliferation, hemopoiesis, and lymphocyte proliferation. Acts upstream of or within several processes, including dendritic cell homeostasis, hematopoietic or lymphoid organ development, and regulation of cytokine production. Located in external side of plasma membrane. Is expressed in several structures, including brain, dorsal aorta, immune system, reproductive system, and spinal cord. Used to study acute myeloid leukemia and juvenile myelomonocytic leukemia. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia, acute myeloid leukemia, colorectal adenocarcinoma, hepatocellular carcinoma, and prostate cancer. Orthologous to human FLT3 (fms related receptor tyrosine kinase 3). Synonyma: Flk2, Ly72, wmfl, CD135, Flk-2, Flt-3, B230315G04