Caspase-1 Rabbit mAb

Enables cysteine-type endopeptidase activity. Involved in several processes, including AIM2 inflammasome complex assembly, positive regulation of canonical NF-kappaB signal transduction, and positive regulation of interleukin-1 beta production. Acts upstream of or within several processes, including membrane hyperpolarization, mitochondrial depolarization, and positive regulation of cytokine production. Located in extracellular region. Part of IPAF inflammasome complex. Is active in cytosol. Is expressed in several structures, including forelimb mesenchyme, knee joint, oocyte, small intestine, and telencephalon. Orthologous to human CASP1 (caspase 1). Synonyma: ICE, Il1bc