STING/TMEM173 Rabbit pAb

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. Synonyma: ERIS, MITA, MPYS, SAVI, NET23, STING, hMITA, hSTING, TMEM173, STING-beta, STING/TMEM173