ATIC Rabbit pAb

This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. Synonyma: PURH, AICAR, AICARFT, IMPCHASE, HEL-S-70p, ATIC