GLI2 Rabbit pAb

Enables DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding activity, and promoter-specific chromatin binding activity. Acts upstream of or within several processes, including animal organ development, chordate embryonic development, and regulation of smoothened signaling pathway. Located in several cellular components, including axoneme, ciliary tip, and nuclear speck. Is expressed in several structures, including central nervous system, embryo mesenchyme, eye, genitourinary system, and jaw. Human ortholog(s) of this gene implicated in Culler-Jones syndrome, holoprosencephaly 9, and spina bifida. Orthologous to human GLI2 (GLI family zinc finger 2). Synonyma: GLI2, CJS, HPE9, PHS2, THP1, THP2, Gli2