Phospho-IGF1R-Y1165/1166/INSR-Y1189/1190 Rabbit pAb

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014] Synonyma: IGF1R/INSR, Phospho-IGF1R-Y1165/1166/INSR-Y1189/1190