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Human PTK7 Monoclonal Antibody

Human PTK7 Monoclonal Antibody
Poznámka k dopravě
Dopravné k jednorázové objednávce činí 2.000 Kč, které rozpočítáváme při fakturaci do cen za zboží. V rámci snížení nákladů na dopravu se snažíme konsolidovat objednávky tak, aby se tato suma rozdělila mezi maximum zákazníků. Před objednáním u dodavatele jsou všichni zákazníci vždy předem informovaní o aktuální výši dopravy.
Human PTK7 Monoclonal Antibody
What is cofetuzumab biosimilar research grade? Cofetuzumab is a humanized IgG1-kappa monoclonal anti...
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  • Výrobce: ABclonal
  • Kód výrobce: ABC-YR0160

Dostupné možnosti

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Dotaz na zboží

Mgr. Lenka Šídová (Kasalová)

Produktový specialista - Buněčná biologie (ext.)

What is cofetuzumab biosimilar research grade? Cofetuzumab is a humanized IgG1-kappa monoclonal antibody against PTK7, which is a tumor-associated antigen (TAA) and overexpressed on a variety of cancer cells. Cofetuzumab pelidotin is an antibody-drug conjugate (ADC) composed of cofetuzumab linked, via a cleavable valine-citrulline linker, to an analog of the auristatin microtubule inhibitor dolastatin 10, auristatin-0101, with potential antineoplastic activity. Upon administration, cofetuzumab pelidotin targets and binds to PTK7 expressed on tumor cells. Upon binding, internalization and cleavage, auristatin-0101 binds to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and apoptosis of PTK7-expressing tumor cells. Cofetuzumab biosimilar uses the same protein sequences as the therapeutic antibody cofetuzumab. Synonyma: CCK-4, CCK4
Technické specifikace
Doprava a skladování Store at 2 - 8℃. 2 - 8°C for up to 4 weeks and -80°C for long term storage (Avoid repeated freezing and thawing)
Vlastnosti
Aplikace ELISA,neutralization,functional assays such as bioanalytical PK and ADA assays,and those assays for studying biological pathways
Fluorochrom <5% Determined by SECP
Klon Biosimilar
Předpokládaná křížová reaktivita <1EU/mg (<0.001EU/μg)Determined by LAL gel clotting assay
Původ 0.2 μm filtration
Specifita Cofetuzumab Biosimilar
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