Anti-FBXW7 (hCdc4) Antibody

FBXW7 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human FBXW7 and is antigen affinity purified. It is great for use in WB. Cyclin E, one of the activators of the cyclin-dependent kinase Cdk2, is critical for the initiation of DNA replication and other S-phase functions. The proper timing and amplitude of cyclin E expression seem to be important, because elevated levels of cyclin E have been associated with a variety of malignancies and constitutive expression of cyclin E leads to genomic instability. Phosphorylated cyclin E depends on the novel human gene, hCdc4, that was found to be mutated in a cell line derived from breast cancer that expressed extremely high levels of cyclin E.