CD58 PE

The clone TS2/9 recognizes a 45-70 kD cell surface protein, currently known as CD58. It is a member of the immunoglobulin superfamily previously known as lymphocyte function-associated antigen 3 (LFA-3). Both hematopoietic and non-hematopoietic cells including B and T cells, monocytes, erythrocytes, endothelial cells, epithelial cells, and fibroblasts express CD58. CD58 has two isoforms and is highly expressed on antigen specific memory T cells and as well as dendritic cells. The CD58 mediates cellular adhesion and participates in signal transduction when it binds to its ligand, the CD2 antigen. Cellular interactions regulated by the CD58/CD2 antigens are involved in the antigen-independent adhesion pathway and cytotoxic T lymphocyte (CTL) activity.