CD66b iFluor™ 647

G10F5 recognizes 95-100 kD glycosylphosphatidylinositol (GPI)-linked protein known as CD66b. CD66b is a member of carcinoembryonic antigen (CEA)-like subfamily of the immunoglobulin superfamily and considered as a non-specific cross-reacting antigens (NCA) which is increased in granulocytes after in vitro stimulation with Ca2+, PMA. It is mostly expressed on granulocytes and causes activation of neutrophils through reacting heterophilic adhesion with CD66c. Research findings suggest CD66b is useful in the study of various normal and pathological conditions, including: cancer, embryonic development, bacterial infection, viral infection, inflammation, pregnancy, bile transport, cell adhesion, etc.