CD23 APC

The clone HD50 is a mouse monoclonal antibody selectively binds with the 45 kD type II integral membrane glycoprotein having a low-affinity receptor for immunoglobulin (Ig)E commonly known as CD23 or FcεRII. CD23 is the only FcR which does not belong to the immunoglobulin gene superfamily and is expressed on mature B cells, monocytes, eosinophils, platelets and dendritic cells. Similar to the most FcR, soluble forms of CD23 (sCD23) are released into extracellular fluids. CD23 interacts with CD21, CD11b and CD11c indicates that CD23 should be viewed not only as a low affinity IgE receptor but also as an adhesion molecule involved in cell-cell interaction. Presence of cell surface and soluble CD23 in serum is considered as one of the prognostic markers of chronic lymphocytic leukemia (CLL).