Casein Kinase 1 alpha (CSNK1A1) Rabbit mAb

Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway, peptidyl-serine phosphorylation, and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in centrosome, cytosol, and nuclear speck. Part of beta-catenin destruction complex. Colocalizes with keratin filament and mRNA cleavage and polyadenylation specificity factor complex. Biomarker of Alzheimer's disease and inclusion body myositis.