Mitofusin 2 Rabbit pAb

Predicted to enable several functions, including GTP binding activity, GTPase activity, and enzyme binding activity. Involved in mitochondrial fusion, parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization, and positive regulation of cold-induced thermogenesis. Acts upstream of or within blastocyst formation and camera-type eye morphogenesis. Located in microtubule cytoskeleton and mitochondrion. Is expressed in several structures, including brain, early conceptus, eye, heart, and oocyte. Used to study Charcot-Marie-Tooth disease type 2A2A. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease, Charcot-Marie-Tooth disease type 2A2A, Charcot-Marie-Tooth disease type 2A2B, and Charcot-Marie-Tooth disease type 6. Orthologous to human MFN2 (mitofusin 2).