Topors Rabbit pAb

Predicted to enable several functions, including DNA topoisomerase binding activity, antigen binding activity, and ubiquitin-like protein transferase activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, positive regulation of transcription, DNA-templated, and regulation of cell population proliferation. Located in ciliary basal body, nucleus, and photoreceptor connecting cilium. Is expressed in skin. Human ortholog(s) of this gene implicated in retinitis pigmentosa 31. Orthologous to human TOPORS (TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase). Synonyma: LUN, TP53BPL, p53BP3/LUN, Topors