AIF1/IBA1 Rabbit mAb

Enables actin filament binding activity and calcium ion binding activity. Involved in several processes, including Rac protein signal transduction, actin filament organization, and ruffle assembly. Acts upstream of or within actin filament bundle assembly. Located in several cellular components, including actin filament, phagocytic cup, and ruffle membrane. Is expressed in adrenal cortex, central nervous system, embryo mesenchyme, and retina. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human AIF1 (allograft inflammatory factor 1). Synonyma: G1, Iba1, AIF-1, D17H6S50E, AIF1/IBA1