ABflo® 488 Rabbit anti-Human IL-17RB mAb

The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. Synonyma: IL17RB, CRL4, EVI27, IL17BR, IL17RH1, interleukin-17 receptor B