DR4 Rabbit mAb

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Synonyma: TNFRSF10A, APO2, CD261, DR4, TRAILR-1, TRAILR1, TNF receptor superfamily member 10a