IκBα Rabbit mAb

Enables NF-kappaB binding activity and heat shock protein binding activity. Involved in several processes, including cytoplasmic sequestering of NF-kappaB, leukocyte migration involved in inflammatory response, and liver regeneration. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in cytosol and nucleus. Part of protein-containing complex. Used to study gastritis, pulmonary emphysema, and sciatic neuropathy. Biomarker of several diseases, including acute necrotizing pancreatitis, alcoholic hepatitis, artery disease (multiple), middle cerebral artery infarction, and toxic shock syndrome. Human ortholog(s) of this gene implicated in several diseases, including childhood-onset asthma, hematologic cancer (multiple), hepatitis B, hepatitis C, and lung disease (multiple). Orthologous to human NFKBIA (NFKB inhibitor alpha).