PE Rabbit anti-Mouse CD130/gp130 mAb

Contributes to interleukin-11 binding activity and interleukin-11 receptor activity. Involved in interleukin-6-mediated signaling pathway, intestinal epithelial cell development, and positive regulation of Notch signaling pathway. Acts upstream of or within several processes, including glycogen metabolic process, positive regulation of astrocyte differentiation, and regulation of Notch signaling pathway. Located in dendrite, external side of plasma membrane, and neuronal cell body. Is expressed in several structures, including alimentary system, brain, early conceptus, immune system, and reproductive system. Used to study rheumatoid arthritis and stomach cancer. Human ortholog(s) of this gene implicated in arteriosclerosis, hyper IgE recurrent infection syndrome 4, and hyperandrogenism. Orthologous to human IL6ST (interleukin 6 cytokine family signal transducer).