CD105/Endoglin Rabbit mAb

Enables protein homodimerization activity and transforming growth factor beta binding activity. Involved in several processes, including circulatory system development, positive regulation of cell differentiation, and regulation of gene expression. Acts upstream of or within circulatory system development and positive regulation of angiogenesis. Located in endothelial microparticle. Is expressed in several structures, including brain, cardiovascular system, extraembryonic vascular system, and lung. Used to study arteriovenous malformations of the brain and hereditary hemorrhagic telangiectasia. Human ortholog(s) of this gene implicated in arteriovenous malformation, arteriovenous malformations of the brain, breast cancer, hereditary hemorrhagic telangiectasia, and intracranial aneurysm. Orthologous to human ENG (endoglin).