Integrin alpha 1/CD49a Rabbit mAb

Predicted to enable collagen binding activity involved in cell-matrix adhesion, protein phosphatase binding activity, and signaling receptor binding activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway. Acts upstream of or within cell adhesion, cellular extravasation, and neutrophil chemotaxis. Located in basal part of cell and external side of plasma membrane. Is expressed in blood vessel endothelium, embryo mesenchyme, intestine smooth muscle, and lung. Orthologous to human ITGA1 (integrin subunit alpha 1). Synonyma: Vla1, CD49A, E130012M19Rik