ABflo® 450 Rabbit anti-Mouse/Rat CD31/PECAM1 mAb

Predicted to enable protein homodimerization activity, protein phosphatase binding activity, and transmembrane signaling receptor activity. Acts upstream of or within several processes, including Rho protein signal transduction, endothelial cell morphogenesis, and positive regulation of tyrosine phosphorylation of STAT protein. Located in several cellular components, including cell-cell contact zone, external side of plasma membrane, and smooth muscle contractile fiber. Is expressed in several structures, including alimentary system, cardiovascular system, central nervous system, extraembryonic component, and genitourinary system. Human ortholog(s) of this gene implicated in coronary artery disease (multiple), lung non-small cell carcinoma, neuroblastoma, and psoriatic arthritis. Orthologous to human PECAM1 (platelet and endothelial cell adhesion molecule 1).