IRS1 Rabbit pAb

Enables phosphatidylinositol 3-kinase activator activity, phosphatidylinositol 3-kinase binding activity, and transmembrane receptor protein tyrosine kinase adaptor activity. Involved in cellular response to fatty acid, insulin receptor signaling pathway, and insulin-like growth factor receptor signaling pathway. Acts upstream of or within several processes, including cellular response to insulin stimulus, positive regulation of epithelial cell migration, and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in several cellular components, including ciliary basal body, nucleus, and plasma membrane. Is expressed in several structures, including alimentary system, brain, genitourinary system, hemolymphoid system gland, and liver and biliary system. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease, coronary artery disease, type 2 diabetes mellitus, and uterine fibroid. Orthologous to human IRS1 (insulin receptor substrate 1).