GSDMD (Full Length+C terminal) Rabbit mAb

Enables phospholipid binding activity, transcription coactivator activity, and wide pore channel activity. Involved in several processes, including defense response to bacterium, positive regulation of interleukin-1 beta production, and protein-containing complex assembly. Acts upstream of or within ceramide biosynthetic process, plasma membrane repair, and protein maturation. Located in cytosol, extracellular space, and mitochondrial membrane. Part of NLRP3 inflammasome complex. Is active in plasma membrane. Is expressed in several structures, including aorta, gut, liver, metanephros, and spleen. Orthologous to human GSDMD (gasdermin D). Synonyma: DF5L, M2-4, Dfna5l, GsdmD-1, Gsdmdc1, 1810036L03Rik