Delta-sarcoglycan (SGCD) Rabbit pAb

The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. Synonyma: SGD, DAGD, 35DAG, CMD1L, SGCDP, LGMDR6, SG-delta, Delta-sarcoglycan (SGCD)