KDM6A Rabbit pAb

Enables DNA binding activity, histone H3-tri/di-methyl-lysine-27 demethylase activity, and identical protein binding activity. Involved in chromatin remodeling. Acts upstream of or within several processes, including chordate embryonic development, embryonic morphogenesis, and histone H3-K27 demethylation. Located in nucleus. Part of histone methyltransferase complex. Is expressed in several structures, including early conceptus, gonad, liver, lung, and spleen. Used to study chronic myelomonocytic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Kabuki syndrome, bladder urothelial carcinoma, gastrointestinal system cancer (multiple), lung carcinoma (multiple), and triple-receptor negative breast cancer. Orthologous to human KDM6A (lysine demethylase 6A).