Anti-CLAC-P (NC2-1 region) Antibody

CLAC-P (NC2-1 region) rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human and mouse CLAC-P (NC2-1 region) and is antigen affinity purified. It is great for use in WB. Antibodies against senile plaque (SP) amyloid obtained a clone 9D2, which labeled amyloid fibrils in SPs and reacted with approximately 50/100 kDa polypeptides in Alzheimer's disease (AD) brains. The 9D2 antigen was identified as CLAC (collagen-like Alzheimer amyloid plaque component), and its precursor as CLAC-P/collagen type XXV. Both secreted and membrane-tethered forms of CLAC-P/collagen type XXV specifically bound to fibrillized Abeta, implicating these proteins in beta-amyloidogenesis and neuronal degeneration in AD