CD45 iFluor™ 488

The clone F10-89-4, a mouse monoclonal antibody, recognizes a hematopoietic cell surface antigen known as CD45 which is present on all human leukocytes including lymphocytes, monocytes, granulocytes, eosinophils, and basophils in peripheral blood. CD45 has a role in signal transduction, modifying signals from other surface molecules. The CD45 antibody has been reported to react weakly with mature circulating erythrocytes and platelets. The antibody recognizes the human leukocyte common antigen which is found on cells from spleen, lymph nodes, 83% bone marrow cells, and granulocytes. The antigen recognized by F10-89-4 is a glycoprotein with a molecular weight of 190 kDa to 215 kDa.